I sæson 6 af Greys Anatomy fusioneres hospitalet Seattle Grace med et konkurrerende hospital. Dette afstedkommer voldsom konkurrence de ansatte imellem og deraf dramaer. DVDerne rummer 24 episoder, samt ekstramateriale med blandt andet en forlænget sæsonfinale: EP 1 Good Mourning, Ep 2 Goodbye, EP 3 I Always Feel Like Somebodys Watchin Me, Ep. 4 Tainted Obligation, Ep. 5 Invasion, Ep. 6 I Saw What I Saw, Ep. 7 Give Peace a Chance, Ep. 8 Invest in Love, Ep. 9 New History, Ep. 10 Holidaze, Ep. 11 Blink, Ep. 12 I Like You So Much Better When Youre Naked, Ep. 13 State of Love and Trust, Ep. 14 Valentines Day Massacre, Ep. 15 The Time Warp, Ep. 16 Perfect Little Accident, Ep. 17 Push, Ep. 18 Suicide Is Painless, Ep. 19 Sympathy for the Parents Ep. 20 Hook, Line and Sinner, Ep. 21 How Insensitive, Ep. 22 Shiny Happy People, Ep. 23 Sanctuary; Death and All His Friends.
